Drug Interactions With Boceprevir
Certain Calcium Channel Blockers
Boceprevir may increase blood levels of certain calcium channel blockers, possibly increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely if you take these drugs together and adjust your calcium blocker dosage if needed.
Dexamethasone can decrease blood levels of boceprevir, potentially making it less effective. Blood levels of certain other corticosteroids (inhaled budesonide and fluticasone) can be increased in the body when combined with boceprevir. If possible, boceprevir should not be used with dexamethasone or inhaled budesonide or fluticasone.
Boceprevir can increase blood levels of cyclosporine, tacrolimus, and sirolimus, possibly increasing the risk for side effects. If you take these medications together, your healthcare provider will need to monitor you more closely for potential side effects. Your healthcare provider will check your blood levels of your immunosuppressant and decrease your dose as necessary.
Certain Statin Medications
Boceprevir can increase the blood levels of certain statin medications, potentially increasing your risk for side effects, including statin-related muscle problems. You should not take lovastatin or simvastatin while taking boceprevir. A person's atorvastatin dosage should not exceed 20 mg a day when used with boceprevir. If you have high cholesterol, your healthcare provider may choose to give you a different statin during boceprevir treatment.