Drug Interactions With Boceprevir
Methadone and Buprenorphine
Taking boceprevir with methadone or buprenorphine could increase or decrease the levels of these medicines in your body. Your healthcare provider will likely monitor you more closely if you take methadone or buprenorphine with boceprevir and adjust your dose if needed.
Non-nucleoside Reverse Transcriptase Inhibitors
Combining boceprevir with efavirenz may result in lower blood levels of boceprevir, possibly decreasing its effectiveness. It is recommended that these medications not be used together.
P-glycoprotein (Pgp) Inhibitors
P-glycoprotein is a protein found in the body. One of its roles is to help remove substances, such as medications, out of the tissues so they can be excreted through the urine or feces. Pgp helps remove boceprevir from the body. Medications known as Pgp inhibitors decrease the activity of Pgp.
Thus, taking boceprevir with one of these Pgp inhibitors causes boceprevir to be removed more slowly, potentially increasing the amount of boceprevir in your body and increasing your risk for serious side effects. Your healthcare provider may choose to monitor you more closely for side effects if you take boceprevir with a Pgp inhibitor.
Phosphodiesterase Type 5 Inhibitors (PDE5 Inhibitors)
Taking boceprevir with a PDE5 inhibitor may increase the level of the PDE5 inhibitor in your body, increasing your risk for potentially serious side effects. Talk to your healthcare provider before taking these medications together. PDE5 inhibitors should not be taken with boceprevir when they are being used to treat pulmonary hypertension (high blood pressure in the blood vessels of the lungs).
You should not take boceprevir if you take pimozide. Taking these medications together may increase the risk for heart arrhythmias (an abnormal heart rhythm). Talk to your healthcare provider about this potential interaction before taking these drugs together.