Drug Interactions With Boceprevir
Ritonavir has been shown to decrease boceprevir blood levels, potentially making it less effective. It is unknown if other protease inhibitors have the same effect on boceprevir. Talk to your healthcare provider before taking these medications together. Additionally, VICTRELISboceprevir can lower the level of protease inhibitors in the blood, making them less effective. In general, such combinations are not recommended.
Rifabutin can decrease levels of boceprevir in your body, potentially making it less effective. Boceprevir may increase blood levels of rifabutin, potentially increasing your risk for side effects. It is recommended that these drugs not be used together.
Boceprevir may increase blood levels of salmeterol, possibly increasing your risk for potentially serious side effects, including heart rhythm problems. It is recommended that these drugs not be taken together. Talk to your healthcare provider about this potential interaction before combining salmeterol with boceprevir.
Taking boceprevir with trazodone could increase the level of trazodone in your body, potentially increasing your risk for side effects, such as dizziness and low blood pressure. Your healthcare provider may need to give you a lower trazodone dosage while you take boceprevir.
Boceprevir can have variable effects on warfarin, potentially increasing or decreasing warfarin blood levels. Your healthcare provider will likely monitor you more closely by checking your international normalized ratio (INR) if you take warfarin with boceprevir.