(Click Engerix-B Uses for more information on what the vaccine is used for, including possible off-label indications.)
Thimerosal Content and Other Concerns
Engerix-B does not contain thimerosal, a mercury-containing preservative. People who are concerned about exposure to this substance can be confident that this vaccine has no thimerosal -- not even trace amounts.
Some people also are concerned about the aluminum content of vaccines. The pediatric version of this vaccine (used for children and teens) contains 0.25 mg of aluminum per dose, while the adult version contains 0.5 mg per dose.
This vaccine is not made from human fetal components or animal components, unlike some vaccines.
Engerix-B is made by GlaxoSmithKline Biologicals.
This vaccine contains hepatitis B surface antigens, which are proteins on the outer surface of the virus that can be recognized by the immune system.
Unlike older versions of the hepatitis vaccine, currently available vaccines (including Engerix-B) are not made using human blood products. Instead, they are made using recombinant DNA technology. Engerix-B is not "live," so there is absolutely no chance that a person could get hepatitis B from this vaccine.
Simply stated, this vaccine "tricks" the body into thinking it has been exposed to the
hepatitis B virus. The body produces antibodies in response that will help fight infection if future exposure occurs.
Some general considerations to keep in mind with Engerix-B include the following:
- This vaccine is typically given as three or four doses, depending on the age of the individual and the specific dosage used.
- For infants, this vaccine is injected into a muscle (intramuscularly), usually in the thigh. In adults and older children, the upper arm can be used.
- If absolutely necessary, Engerix-B can be injected subcutaneously (just under the skin), instead of intramuscularly. However, this method of injection might reduce the effectiveness of the vaccine and may increase the risk of certain side effects, such as lumps at the injection site.
- People can be vaccinated if they have a minor illness, such as the common cold. However, the Engerix-B vaccine should be postponed if the individual is moderately or severely ill.
Engerix-B Dosing Information
The specific dose and schedule for this vaccine will vary, depending on the following factors:
- Your age
- Your previous vaccination history
- Your kidney function, especially if you are on dialysis.
Just like any vaccine, Engerix-B may cause side effects. However, not everyone who receives the vaccine will experience problems. In fact, most people tolerate it well, with only minor side effects, if any. If adverse reactions do occur, in most cases, they are minor and either require no treatment or can be treated easily by you or your healthcare provider. Serious reactions are less common.
Some of the most common side effects seen with Engerix-B include but are not limited to:
- Fatigue
- Dizziness
- Headaches
- Fever
- Injection site reactions, such as pain, redness, or swelling.
(Click Engerix-B Side Effects to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
What Should I Tell My Healthcare Provider?
Before receiving the Engerix-B vaccine, talk with your healthcare provider if you have:
- Multiple sclerosis (MS)
- An immune-suppressing condition, such as HIV or AIDS, diabetes, or cancer
- Had any sort of a reaction to a vaccine
- A moderate or severe illness
- Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
Make sure to tell your healthcare provider about all of the medicines you take, including prescription and nonprescription drugs, vitamins, and herbal supplements.
How Should Engerix-B Be Stored?
Engerix-B should be stored in the refrigerator. The vaccine should never be frozen.
The vaccine is available in the following forms and strengths:
- Engerix-B pediatric/adolescent dose (10 mcg/0.5 mL), available in single-dose vials and prefilled syringes
- Engerix-B adult dose (20 mcg/1 mL), available in single-dose vials and prefilled syringes.
The prefilled syringes (but not the vials) contain dry natural latex rubber, which can cause allergic reactions in people sensitive to latex.
Is There a Generic Version?
