Hepatitis Home > Epivir

Epivir is a medicine that can be prescribed to treat AIDS and HIV. It is taken with other HIV medications as part of an HIV "cocktail." A certain form of Epivir is also approved to treat chronic hepatitis B. Most people tolerate the medication well, but potential side effects include fatigue, abdominal pain, and headaches.

What Is Epivir?

Epivir® (lamivudine) is a prescription medication used to treat AIDS and HIV. It is approved only to be combined with other medications for the treatment of HIV. It is not approved to be used by itself. Epivir-HBV® (which also contains lamivudine) is approved to treat chronic hepatitis B.
(Click Epivir Uses for more information on what it is used for, including possible off-label uses.)

Who Makes Epivir?

The medication is made by GlaxoSmithKline.

How Does It Work?

Epivir belongs to group of medications known as nucleoside reverse transcriptase inhibitors (NRTIs). NRTI medications work by blocking a process that the HIV and hepatitis B viruses need in order to multiply.
HIV (the human immunodeficiency virus) is the virus that is responsible for AIDS, and HBV (the hepatitis B virus) is responsible for hepatitis B infection. Like other viruses, HIV and HBV must use a person's own cells to reproduce. However, HIV and HBV are different from many other viruses because they must first convert their genetic material from RNA to DNA. It is the DNA genes that allow HIV and HBV to multiply.
HIV and HBV convert their genetic material into DNA by using a special protein called the reverse transcriptase enzyme. To create DNA, this enzyme uses several different molecular building blocks.
Epivir works by tricking reverse transcriptase into thinking it is one of these molecular building blocks. However, it is just different enough that when used to create DNA, Epivir actually stops the DNA from being made. Without DNA, HIV and HBV cannot multiply. It is important to understand that this drug is not a cure for HIV, AIDS, or hepatitis B.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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