Hepatitis Home > Sofosbuvir Dosage

The standard recommended dose of sofosbuvir is 400 mg once daily. However, the length of time your treatment lasts will be based on the type of hepatitis C virus you have and various other factors. Sofosbuvir is used in combination with other medications, and this combined therapy can last anywhere from 12 weeks to 48 weeks.

An Introduction to Your Dosage of Sofosbuvir

There is only one standard recommended dose of sofosbuvir (Sovaldi™). However, the length of treatment will depend on a variety of factors, including:
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Recommended Sofosbuvir Dosing Guidelines

The recommended dosage for all types of hepatitis C is sofosbuvir 400 mg once daily, taken by mouth, with or without food. How long you take it will vary, as follows:
  • Genotype 1 or 4 -- Sofosbuvir plus peginterferon alfa plus ribavirin for 12 weeks
  • Genotype 2 -- Sofosbuvir plus ribavirin for 12 weeks
  • Genotype 3 -- Sofosbuvir plus ribavirin for 24 weeks.
For people with genotype 1 who cannot take peginterferon, a regimen of sofosbuvir plus ribavirin for 24 weeks is acceptable. Sofosbuvir is also approved to be used for up to 48 weeks in people with hepatitis C awaiting liver transplant, to help reduce the risk of reinfecting the new liver.

General Information on Taking Sofosbuvir

Some considerations to keep in mind during treatment with sofosbuvir include the following:
  • Sofosbuvir comes in tablet form. It is usually taken by mouth once a day, with or without food, for 12 to 48 weeks.
  • Make sure to take your dose of sofosbuvir at the same time each day to keep an even level of it in your bloodstream.
  • For the medication to work properly, it must be taken as prescribed. Do not stop taking sofosbuvir unless your healthcare provider tells you to do so. Missing doses can increase the chance of the virus becoming resistant to the medication, which can make the medication less effective.
  • If you are unsure about anything related to your sofosbuvir dosage, please talk with your healthcare provider, nurse, or pharmacist.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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