Drug Interactions With Sofosbuvir

You run the risk of drug interactions with sofosbuvir if you are taking certain antibiotics, seizure medications, or even supplements like St. John's wort. To help avoid problems, your healthcare provider will ask you about any vitamins, supplements, or other medications you are taking. You may need to avoid certain products during treatment.

An Overview of Sofosbuvir Interactions

Sofosbuvir (Sovaldi™) can potentially interact with a number of other medications. Some of the medicines that may lead to interactions with sofosbuvir include but are not limited to:
 
  • Certain antibiotics, such as:
    • Rifabutin (Mycobutin®)
    • Rifampin (Rifadin®, Rifamate®, Rifater®, Rimactane®)
    • Rifapentine (Priftin®)
     

More Detail on Drug Interactions With Sofosbuvir

The following sections explain in detail the potentially negative reactions that can occur when any of the drugs mentioned above are combined with sofosbuvir.
 
Certain Antibiotics
Some antibiotics can decrease the level of sofosbuvir in the blood, making it less effective. In general, such combinations should be avoided. Rifampin, in particular, should never be combined with sofosbuvir.
 
Certain Seizure Medications
Some seizure medications can decrease the level of sofosbuvir in the blood, making it less effective. In general, such combinations should be avoided.   
 
St. John's Wort
St. John's wort can significantly lower the level of sofosbuvir in the blood, making it significantly less effective. Never take these medications together.
 
Tipranavir/Ritonavir
The combination of tipranavir and ritonavir can decrease the level of sofosbuvir in the blood, making it less effective. In general, these medications should not be used together.
 

Sofosbuvir Drug Information

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