Precautions and Warnings With Sofosbuvir

Drug interactions, allergic reactions, and other potentially serious problems may occur in some people taking sofosbuvir. If you have certain problems with your liver or kidneys, ask your healthcare provider if sofosbuvir will increase your risk for complications. There are also important precautions for women who are pregnant or nursing, along with warnings for men who have a partner who is pregnant.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking sofosbuvir (Sovaldi™) if you have:
   
Also, let your healthcare provider know if you are:
 
  • Pregnant, thinking of becoming pregnant, or have a female partner who is pregnant
  • Breastfeeding.
 
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
 

Specific Sofosbuvir Precautions and Warnings

Some warnings and precautions to be aware of prior to taking this drug include the following:
 
  • Sofosbuvir has not been studied in people with "decompensated" cirrhosis of the liver, although it has been studied in people with liver cancer awaiting liver transplantation, as well as in people in all stages of liver failure.
 
  • Sofosbuvir can interact with a number of other medications. Some medications should not be used in combination with sofosbuvir (see Drug Interactions With Sofosbuvir).
 
  • Sofosbuvir is a pregnancy Category B medication, which usually means a drug is fairly safe for use during pregnancy. However, sofosbuvir is always used in combination with ribavirin, which is a pregnancy Category X medication. Therefore, sofosbuvir should not be used in pregnant women, or in men whose partner is pregnant. Women must use two forms of birth control during treatment (see Sovaldi and Pregnancy).
 
  • It is unknown if sofosbuvir passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Sovaldi and Breastfeeding).
 

Sofosbuvir Drug Information

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