You should talk with your healthcare provider prior to taking this medication if you have:
- Liver disease (other than hepatitis C), such as hepatitis B or cirrhosis
- Had a liver transplant
- Kidney disease
- Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
- Pregnant, thinking of becoming pregnant, or have a female partner who is pregnant (see Sovaldi and Pregnancy)
- Breastfeeding (see Sovaldi and Breastfeeding).
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Sofosbuvir to learn more, including information on who should not take the drug.)
Sofosbuvir is classified as a hepatitis C virus (HCV) nucleotide analog NS5B polymerase inhibitor. It works by interfering with the activity of NS5B polymerase, an enzyme crucial to the replication of the virus. By inhibiting NS5B polymerase, sofosbuvir helps stop the virus from reproducing itself.
Some general considerations to keep in mind during treatment with sofosbuvir include the following:
- Sofosbuvir comes in tablet form. It is usually taken by mouth once a day, with or without food, for 12 to 48 weeks.
- Make sure to take this medication at the same time each day to keep an even level of it in your bloodstream.
- For the medication to work properly, it must be taken as prescribed. Do not stop taking sofosbuvir unless your healthcare provider tells you to do so. Missing doses can increase the chance of the virus becoming resistant to the medication, which can make the medication less effective.