Drug Interactions With Telaprevir
Certain Anti-Seizure Medications
Taking telaprevir with certain anti-seizure medications can affect the blood levels of telaprevir and of the seizure medicines. Telaprevir may increase blood levels of carbamazepine, and could increase or decrease blood levels of phenytoin and phenobarbital. In addition, any of those seizure medications may decrease telaprevir blood levels, potentially making it less effective. Talk to your healthcare provider before taking these medications together.
Telaprevir can increase blood levels of certain benzodiazepines, potentially increasing your risk for side effects. It can also decrease blood levels of zolpidem.
Talk to your healthcare provider before taking telaprevir with one of these medicines. He or she may need to adjust the dose of your benzodiazepine or sedative. Oral midazolam or oral triazolam and telaprevir should not be taken together. Injectable midazolam should only be given with telaprevir in a healthcare setting, where appropriate monitoring is possible.
Telaprevir can increase blood levels of cyclosporine, tacrolimus, and sirolimus, possibly increasing the risk for side effects. If you take these medications together, your healthcare provider will need to monitor you more closely for potential side effects. He or she will check your blood levels of your immunosuppressant, and decrease your dose as necessary.
Telaprevir increases the risk of dangerous muscle problems with certain statins). It should never be combined with lovastatin or simvastatin, and combining it with atorvastatin is not recommended. Telaprevir may be combined with fluvastatin, pitavastatin, pravastatin, or rosuvastatin, although extra caution and monitoring are required.