Drug Interactions With Telaprevir

Cisapride
Telaprevir and cisapride should never be combined, due to the increased risk of a dangerous irregular heart rhythm (arrhythmia).
  
Colchicine
Combining telaprevir with colchicine could increase the levels of colchicine in your body, increasing your risk for potentially serious side effects. People with kidney and liver disease (other than hepatitis C) should not take these medicines together. If they are taken together, a lower colchicine dose should be used.
 
Corticosteroids
Combining telaprevir with corticosteroids could result in increased levels of corticosteroids in the bloodstream, which could increase your risk for potentially serious side effects. INCIVEK should not be used with oral, inhaled, or nasal corticosteroid medicines unless absolutely necessary.
 
CYP 3A4 Inducer Medications
The liver breaks down telaprevir using enzymes known as CYP 3A4 enzymes. Medications known as CYP 3A4 inducers can increase the activity of these enzymes. Combining telaprevir with one of these CYP 3A4 inducers may decrease the level of telaprevir in your bloodstream, possibly making it less effective. Talk to your healthcare provider before taking telaprevir with a CYP 3A4 inducer.
 
Telaprevir should never be combined with Rifampin or St. John's wort.
 
CYP 3A4 Inhibitor Medications
The liver breaks down telaprevir using enzymes known as CYP 3A4 enzymes. Medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Combining telaprevir with one of these CYP 3A4 inhibitors may increase the level of telaprevir in your bloodstream, increasing your risk for side effects. Talk to your healthcare provider before taking telaprevir with a CYP 3A4 inhibitor.

Telaprevir Medication Information

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