Drug Interactions With Telaprevir
Non-Nucleoside Reverse Transcriptase Inhibitors
Combining telaprevir with efavirenz may result in lower blood levels of both efavirenz and telaprevir, possibly decreasing the effectiveness of the medications. Combining telaprevir with tenofovir may cause increased levels of tenofovir in the bloodstream, which could increase the risk for tenofovir side effects. Your healthcare provider will need to monitor you more closely if you take these medications together.
P-Glycoprotein (Pgp) Inhibitors
P-glycoprotein is a protein found in the body. One of its roles is to help remove substances, such as medications, out of the tissues so they can be excreted through the urine or feces. Pgp helps remove telaprevir from the body. Certain other medications (known as Pgp inhibitors) decrease the activity of Pgp.
Taking telaprevir with one of these Pgp inhibitors causes telaprevir to be removed more slowly, potentially increasing the amount of telaprevir in your bloodstream and increasing your risk for serious side effects. Your healthcare provider may choose to monitor you more closely for side effects if you take telaprevir with a Pgp inhibitor.
The prescribing information for telaprevir specifically states that combining telaprevir with atorvastatin should be avoided.
Phosphodiesterase Type-5 (PDE5) Inhibitors
Taking telaprevir with a PDE5 inhibitor may increase the level of the PDE5 inhibitor in your bloodstream, potentially increasing your risk for side effects. Talk to your healthcare provider before taking these medications together. Telaprevir should never be combined with sildenafil or tadalafil when these medications are used to treat pulmonary arterial hypertension.
Telaprevir and pimozide should never be combined, due to the increased risk of a dangerous irregular heart rhythm (arrhythmia).
Combining telaprevir with other protease inhibitors can decrease blood levels of telaprevir, while having varying effects on blood levels of the other protease inhibitors. For this reason, it is recommended that these medicines not be used together.